Spider venom-derived peptide induces hyperalgesia in Nav1.7 knockout mice by activating Nav1.9 channels

Spider venom-derived peptide induces hyperalgesia in Nav1.7 knockout mice by activating Nav1.9 channels

Loss of function of Nav1.7 leads to congenital insensitivity to pain in humans. Here the authors found that activation of Nav1.9 can restore nociception in Nav1.7 knockout mice, revealed by a venom-derived peptide as a probe.

Bibliographic Details
Main Authors: Xi Zhou, Tingbin Ma, Luyao Yang, Shuijiao Peng, Lulu Li, Zhouquan Wang, Zhen Xiao, Qingfeng Zhang, Li Wang, Yazhou Huang, Minzhi Chen, Songping Liang, Xianwei Zhang, Jing Yu Liu, Zhonghua Liu
Format: Article
Language:English
Published: Nature Publishing Group 2020-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-16210-y

Internet

https://doi.org/10.1038/s41467-020-16210-y

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