Pathogenic Carboxyl Ester Lipase (CEL) Variants Interact with the Normal CEL Protein in Pancreatic Cells

Pathogenic Carboxyl Ester Lipase (CEL) Variants Interact with the Normal CEL Protein in Pancreatic Cells

Mutations in the gene encoding the digestive enzyme carboxyl ester lipase (CEL) are linked to pancreatic disease. The CEL variant denoted CEL-HYB predisposes to chronic pancreatitis, whereas the CEL-MODY variant causes MODY8, an inherited disorder of endocrine and exocrine pancreatic dysfunction. Bo...

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Bibliographic Details
Main Authors: Monica Dalva, Ida K. Lavik, Khadija El Jellas, Anny Gravdal, Aurelia Lugea, Stephen J. Pandol, Pål R. Njølstad, Richard T. Waldron, Karianne Fjeld, Bente B. Johansson, Anders Molven
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Cells
Subjects:
cel
bsdl
endocytosis
coexpression
cell viability
pancreatic cell models
Online Access:https://www.mdpi.com/2073-4409/9/1/244

Internet

https://www.mdpi.com/2073-4409/9/1/244

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