Denatured state structural property determines protein stabilization by macromolecular crowding: a thermodynamic and structural approach.

Understanding of protein structure and stability gained to date has been acquired through investigations made under dilute conditions where total macromolecular concentration never surpasses 10 g l(-1). However, biological macromolecules are known to evolve and function under crowded intracellular e...

Full description

Bibliographic Details
Main Authors: Shruti Mittal, Laishram Rajendrakumar Singh
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3827121?pdf=render