Culture temperature affects human chondrocyte messenger RNA expression in monolayer and pellet culture systems.

Cell-based therapy has been explored for articular cartilage regeneration. Autologous chondrocyte implantation is a promising cell-based technique for repairing articular cartilage defects. However, there are several issues such as chondrocyte de-differentiation. While numerous studies have been des...

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Bibliographic Details
Main Authors: Akira Ito, Momoko Nagai, Junichi Tajino, Shoki Yamaguchi, Hirotaka Iijima, Xiangkai Zhang, Tomoki Aoyama, Hiroshi Kuroki
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0128082