Isochoric supercooled preservation and revival of human cardiac microtissues

Isochoric supercooled preservation and revival of human cardiac microtissues

Powell-Palm et al. demonstrate sub-zero centigrade preservation and revival of autonomously beating, 3D human induced pluripotent stem cell (hiPSC)-derived cardiac microtissues via isochoric supercooling, without the use of chemical cryoprotectants. Their study suggests that functional 3D engineered...

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Main Authors: Matthew J. Powell-Palm, Verena Charwat, Berenice Charrez, Brian Siemons, Kevin E. Healy, Boris Rubinsky
Format: Article
Language:English
Published: Nature Publishing Group 2021-09-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-021-02650-9
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spelling doaj-e91e22959744442889b1812d5fc408b02021-09-26T11:13:25ZengNature Publishing GroupCommunications Biology2399-36422021-09-01411710.1038/s42003-021-02650-9Isochoric supercooled preservation and revival of human cardiac microtissuesMatthew J. Powell-Palm0Verena Charwat1Berenice Charrez2Brian Siemons3Kevin E. Healy4Boris Rubinsky5Department of Mechanical Engineering, University of California at BerkeleyDepartment of Bioengineering, University of California at BerkeleyDepartment of Bioengineering, University of California at BerkeleyDepartment of Bioengineering, University of California at BerkeleyDepartment of Bioengineering, University of California at BerkeleyDepartment of Mechanical Engineering, University of California at BerkeleyPowell-Palm et al. demonstrate sub-zero centigrade preservation and revival of autonomously beating, 3D human induced pluripotent stem cell (hiPSC)-derived cardiac microtissues via isochoric supercooling, without the use of chemical cryoprotectants. Their study suggests that functional 3D engineered tissues may provide a high-content, low-risk testbed to study complex tissue biopreservation in a genetically human context, and that isochoric supercooling may provide a robust method for preserving and reviving engineered tissues themselves.https://doi.org/10.1038/s42003-021-02650-9
collection DOAJ
language English
format Article
sources DOAJ
author Matthew J. Powell-Palm
Verena Charwat
Berenice Charrez
Brian Siemons
Kevin E. Healy
Boris Rubinsky
spellingShingle Matthew J. Powell-Palm
Verena Charwat
Berenice Charrez
Brian Siemons
Kevin E. Healy
Boris Rubinsky
Isochoric supercooled preservation and revival of human cardiac microtissues
Communications Biology
author_facet Matthew J. Powell-Palm
Verena Charwat
Berenice Charrez
Brian Siemons
Kevin E. Healy
Boris Rubinsky
author_sort Matthew J. Powell-Palm
title Isochoric supercooled preservation and revival of human cardiac microtissues
title_short Isochoric supercooled preservation and revival of human cardiac microtissues
title_full Isochoric supercooled preservation and revival of human cardiac microtissues
title_fullStr Isochoric supercooled preservation and revival of human cardiac microtissues
title_full_unstemmed Isochoric supercooled preservation and revival of human cardiac microtissues
title_sort isochoric supercooled preservation and revival of human cardiac microtissues
publisher Nature Publishing Group
series Communications Biology
issn 2399-3642
publishDate 2021-09-01
description Powell-Palm et al. demonstrate sub-zero centigrade preservation and revival of autonomously beating, 3D human induced pluripotent stem cell (hiPSC)-derived cardiac microtissues via isochoric supercooling, without the use of chemical cryoprotectants. Their study suggests that functional 3D engineered tissues may provide a high-content, low-risk testbed to study complex tissue biopreservation in a genetically human context, and that isochoric supercooling may provide a robust method for preserving and reviving engineered tissues themselves.
url https://doi.org/10.1038/s42003-021-02650-9
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AT briansiemons isochoricsupercooledpreservationandrevivalofhumancardiacmicrotissues
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