Multiple Myeloma Tumor Cells are Selectively Killed by Pharmacologically-dosed Ascorbic Acid

Multiple Myeloma Tumor Cells are Selectively Killed by Pharmacologically-dosed Ascorbic Acid

High-dose chemotherapies to treat multiple myeloma (MM) can be life-threatening due to toxicities to normal cells and there is a need to target only tumor cells and/or lower standard drug dosage without losing efficacy. We show that pharmacologically-dosed ascorbic acid (PAA), in the presence of iro...

Full description

Bibliographic Details
Main Authors: Jiliang Xia, Hongwei Xu, Xiaoyan Zhang, Chantal Allamargot, Kristen L. Coleman, Randy Nessler, Ivana Frech, Guido Tricot, Fenghuang Zhan
Format: Article
Language:English
Published: Elsevier 2017-04-01
Series:EBioMedicine
Subjects:
Multiple myeloma
Pharmacologically-dosed ascorbic acid
Apoptosis-inducing factor 1
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396417300701

Internet

http://www.sciencedirect.com/science/article/pii/S2352396417300701

Similar Items