A Bispecific Antibody-Based Approach for Targeting Mesothelin in Triple Negative Breast Cancer

A Bispecific Antibody-Based Approach for Targeting Mesothelin in Triple Negative Breast Cancer

Triple negative breast cancers (TNBC) remain a major medical challenge due to poor prognosis and limited treatment options. Mesothelin is a glycosyl-phosphatidyl inositol-linked membrane protein with restricted normal expression and high level expression in a large proportion of TNBC, thus qualifyin...

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Bibliographic Details
Main Authors: Joanie Del Bano, Rémy Florès-Florès, Emmanuelle Josselin, Armelle Goubard, Laetitia Ganier, Rémy Castellano, Patrick Chames, Daniel Baty, Brigitte Kerfelec
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Immunology
Subjects:
bispecific antibody (bsAb)
natural killer cells
immunotherapy
triple negative breast cancer (TNBC)
mesothelin (MSLN)
multicellular tumor spheroid model (MCTS)
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01593/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.01593/full

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