DEAD-box RNA Helicase DDX3: Functional Properties and Development of DDX3 Inhibitors as Antiviral and Anticancer Drugs

DEAD-box RNA Helicase DDX3: Functional Properties and Development of DDX3 Inhibitors as Antiviral and Anticancer Drugs

This short review is focused on enzymatic properties of human ATP-dependent RNA helicase DDX3 and the development of antiviral and anticancer drugs targeting cellular helicases. DDX3 belongs to the DEAD-box proteins, a large family of RNA helicases that participate in all aspects of cellular process...

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Bibliographic Details
Main Authors: Marina K. Kukhanova, Inna L. Karpenko, Alexander V. Ivanov
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Molecules
Subjects:
dead-box family rna helicases
physico-chemical properties
antiviral drug
anticancer drug
inhibitors
virus life cycle
Online Access:https://www.mdpi.com/1420-3049/25/4/1015

Internet

https://www.mdpi.com/1420-3049/25/4/1015

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