Sharpin contributes to TNFα dependent NFκB activation and anti-apoptotic signalling in hepatocytes.

Sharpin contributes to TNFα dependent NFκB activation and anti-apoptotic signalling in hepatocytes.

TNFα stimulates both pro- and anti-apoptotic signalling in hepatocytes. Anti-apoptotic signalling depends on a cascade of ubiquitylation steps leading to NFκB activation. Using Sharpin-deficient mice, we show that the ubiquitin binding protein Sharpin interacts with Hoip, an E3 ligase which generate...

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Bibliographic Details
Main Authors: Sabrina Sieber, Nicole Lange, Gwendlyn Kollmorgen, Annette Erhardt, Alexander Quaas, Arthur Gontarewicz, Gabriele Sass, Gisa Tiegs, Hans-Jürgen Kreienkamp
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3253811?pdf=render

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http://europepmc.org/articles/PMC3253811?pdf=render

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