Select targeting of intracellular Toll-interleukin-1 receptor resistance domains for protection against influenza-induced disease

TLRs are a family of PRRs that respond to PAMPs or host-derived Danger-Associated Molecular Patterns (DAMPs) to initiate host inflammation and immune responses. TLR dimerization and recruitment of adapter molecules is critical for intracellular signaling and is mediated through intracellular Toll-In...

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Bibliographic Details
Main Authors: Kari Ann Shirey, Wendy Lai, Lindsey J Brown, Jorge C G Blanco, Robert Beadenkopf, Yajing Wang, Stefanie N Vogel, Greg A Snyder
Format: Article
Language:English
Published: SAGE Publishing 2020-01-01
Series:Innate Immunity
Online Access:https://doi.org/10.1177/1753425919846281