The PAR2 signal peptide prevents premature receptor cleavage and activation.

The PAR2 signal peptide prevents premature receptor cleavage and activation.

Unlike closely related GPCRs, protease-activated receptors (PAR1, PAR2, PAR3, and PAR4) have a predicted signal peptide at their N-terminus, which is encoded by a separate exon, suggesting that the signal peptides of PARs may serve an important and unique function, specific for PARs. In this report,...

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Bibliographic Details
Main Authors: Belinda Liu, Grace Lee, Jiejun Wu, Janise Deming, Chester Kuei, Anthony Harrington, Lien Wang, Jennifer Towne, Timothy Lovenberg, Changlu Liu, Siquan Sun
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0222685

Internet

https://doi.org/10.1371/journal.pone.0222685

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