Molecular bases of neuroserpin function and pathology

Molecular bases of neuroserpin function and pathology

Serpins build a large and evolutionary widespread protein superfamily, hosting members that are mainly Ser-protease inhibitors. Typically, serpins display a conserved core domain composed of three main β-sheets and 9–10 α-helices, for a total of approximately 350 amino acids. Neuroserpin (NS) is mos...

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Bibliographic Details
Main Authors: Caccia Sonia, Ricagno Stefano, Bolognesi Martino
Format: Article
Language:English
Published: De Gruyter 2010-08-01
Series:Biomolecular Concepts
Subjects:
α1-antitrypsin
crystal structure
dementia
familial encephalopathy with ns inclusion bodies (fenib)
neuroserpin (ns)
polymer
protease inhibitor
serine protease
serpinopathies
suicide inhibitor
Online Access:https://doi.org/10.1515/bmc.2010.019

Internet

https://doi.org/10.1515/bmc.2010.019

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