Preclinical effectiveness of selective inhibitor of IRS1/2 NT157 in osteosarcoma cell lines.

Preclinical effectiveness of selective inhibitor of IRS1/2 NT157 in osteosarcoma cell lines.

Osteosarcoma (OS) is the most common primary bone tumor in children and young adults. Several studies have confirmed the involvement of the IGF system in the regulation of OS cell proliferation and differentiation as well as in the protection of cells from chemotherapy. IRS-1 is a critical mediator...

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Bibliographic Details
Main Authors: Cecilia eGarofalo, Mariantonietta eCapristo, Caterina eMancarella, Hadas eReuveni, Piero ePicci, Katia eScotlandi
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-05-01
Series:Frontiers in Endocrinology
Subjects:
Chemotherapy, Adjuvant
Sarcoma
osteosarcoma (OS)
IGF system and signaling
IRS-1
NT157
Online Access:http://journal.frontiersin.org/Journal/10.3389/fendo.2015.00074/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fendo.2015.00074/full

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