The demographic data and the high frequency of chromosome/chromatid breaks as biomarkers for genome integrity have a role in predicting the susceptibility to have Down syndrome in a cohort of Egyptian young-aged mothers

The demographic data and the high frequency of chromosome/chromatid breaks as biomarkers for genome integrity have a role in predicting the susceptibility to have Down syndrome in a cohort of Egyptian young-aged mothers

Abstract Background Down syndrome (DS) is a common numerical chromosome disorder that has its burden on both family and community. The well-known risk factor for chromosome 21 nondisjunction is advanced maternal age which failed to explain the occurrence of Down syndrome born to mothers less than 35...

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Bibliographic Details
Main Authors: Lama M. El-Attar, Noha M. Issa, Hanan Salah Eldin Mahrous
Format: Article
Language:English
Published: SpringerOpen 2019-10-01
Series:Egyptian Journal of Medical Human Genetics
Subjects:
Young mothers
Down syndrome
Risk factors
Chromosome breaks
Consanguinity
Malsegregation
Online Access:http://link.springer.com/article/10.1186/s43042-019-0020-7

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