The demographic data and the high frequency of chromosome/chromatid breaks as biomarkers for genome integrity have a role in predicting the susceptibility to have Down syndrome in a cohort of Egyptian young-aged mothers

The demographic data and the high frequency of chromosome/chromatid breaks as biomarkers for genome integrity have a role in predicting the susceptibility to have Down syndrome in a cohort of Egyptian young-aged mothers

Abstract Background Down syndrome (DS) is a common numerical chromosome disorder that has its burden on both family and community. The well-known risk factor for chromosome 21 nondisjunction is advanced maternal age which failed to explain the occurrence of Down syndrome born to mothers less than 35...

Full description

Bibliographic Details
Main Authors: Lama M. El-Attar, Noha M. Issa, Hanan Salah Eldin Mahrous
Format: Article
Language:English
Published: SpringerOpen 2019-10-01
Series:Egyptian Journal of Medical Human Genetics
Subjects:
Young mothers
Down syndrome
Risk factors
Chromosome breaks
Consanguinity
Malsegregation
Online Access:http://link.springer.com/article/10.1186/s43042-019-0020-7

Internet

http://link.springer.com/article/10.1186/s43042-019-0020-7

Similar Items