The Matricellular Protein R-Spondin 2 Promotes Midbrain Dopaminergic Neurogenesis and Differentiation

Summary: The development of midbrain dopaminergic (mDA) neurons is controlled by multiple morphogens and transcription factors. However, little is known about the role of extracellular matrix proteins in this process. Here we examined the function of roof plate-specific spondins (RSPO1-4) and the fl...

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Bibliographic Details
Main Authors: Daniel Gyllborg, Maqsood Ahmed, Enrique M. Toledo, Spyridon Theofilopoulos, Shanzheng Yang, Charles ffrench-Constant, Ernest Arenas
Format: Article
Language:English
Published: Elsevier 2018-09-01
Series:Stem Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671118303199