Quercetin prevents spinal motor neuron degeneration induced by chronic excitotoxic stimulus by a sirtuin 1-dependent mechanism

Quercetin prevents spinal motor neuron degeneration induced by chronic excitotoxic stimulus by a sirtuin 1-dependent mechanism

Abstract Background Excitotoxicity is a mechanism of foremost importance in the selective motor neuron degeneration characteristic of motor neuron disorders. Effective therapeutic strategies are an unmet need for these disorders. Polyphenols, such as quercetin and resveratrol, are plant-derived comp...

Full description

Bibliographic Details
Main Authors: Rafael Lazo-Gomez, Ricardo Tapia
Format: Article
Language:English
Published: BMC 2017-11-01
Series:Translational Neurodegeneration
Subjects:
Motor neuron disorder
Quercetin
Resveratrol
Sirtuin
Excitotoxicity
Online Access:http://link.springer.com/article/10.1186/s40035-017-0102-8

Internet

http://link.springer.com/article/10.1186/s40035-017-0102-8

Similar Items