Synthesis of IL-6 by hepatocytes is a normal response to common hepatic stimuli.

Exogenous interleukin 6 (IL-6), synthesized at the initiation of the acute phase response, is considered responsible for signaling hepatocytes to produce acute phase proteins. It is widely posited that IL-6 is either delivered to the liver in an endocrine fashion from immune cells at the site of inj...

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Bibliographic Details
Main Authors: Callie A Norris, Mu He, Liang-I Kang, Michael Qi Ding, Josiah E Radder, Meagan M Haynes, Yu Yang, Shirish Paranjpe, William C Bowen, Anne Orr, George K Michalopoulos, Donna B Stolz, Wendy M Mars
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3999098?pdf=render