The decapping activator Edc3 and the Q/N-rich domain of Lsm4 function together to enhance mRNA stability and alter mRNA decay pathway dependence in Saccharomyces cerevisiae

The decapping activator Edc3 and the Q/N-rich domain of Lsm4 function together to enhance mRNA stability and alter mRNA decay pathway dependence in Saccharomyces cerevisiae

The rate and regulation of mRNA decay are major elements in the proper control of gene expression. Edc3 and Lsm4 are two decapping activator proteins that have previously been shown to function in the assembly of RNA granules termed P bodies. Here, we show that deletion of edc3, when combined with a...

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Bibliographic Details
Main Authors: Susanne Huch, Maren Müller, Mridula Muppavarapu, Jessie Gommlich, Vidya Balagopal, Tracy Nissan
Format: Article
Language:English
Published: The Company of Biologists 2016-10-01
Series:Biology Open
Subjects:
P bodies
Deadenylation
Exosome
mRNA decapping
mRNA decay
mRNA stability
Online Access:http://bio.biologists.org/content/5/10/1388

Internet

http://bio.biologists.org/content/5/10/1388

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