Targeting P-Glycoprotein: Nelfinavir Reverses Adriamycin Resistance in K562/ADR Cells

Targeting P-Glycoprotein: Nelfinavir Reverses Adriamycin Resistance in K562/ADR Cells

Background/Aims: The emergence of multidrug resistance (MDR) caused by P-glycoprotein (P-gp) overexpression is a serious obstacle to the treatment of chronic myelocytic leukemia. In recent years, some clinical trials have shown that nelfinavir (NFV), a traditional anti-HIV drug, has anti-cancer effe...

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Bibliographic Details
Main Authors: Wei Liu, Qiang Meng, Yaoting Sun, Changyuan Wang, Xiaokui Huo, Zhihao Liu, Pengyuan Sun, Huijun Sun, Xiaodong Ma, Kexin Liu
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2018-11-01
Series:Cellular Physiology and Biochemistry
Subjects:
Nelfinavir (NFV)
Adriamycin (ADR)
Multidrug resistance (MDR)
P-glycoprotein (P-gp)
Chronic myelocytic leukemia (CML)
Online Access:https://www.karger.com/Article/FullText/495650

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https://www.karger.com/Article/FullText/495650

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