The Short-Stature Homeobox-Containing Gene (shox/SHOX) Is Required for the Regulation of Cell Proliferation and Bone Differentiation in Zebrafish Embryo and Human Mesenchymal Stem Cells

The Short-Stature Homeobox-Containing Gene (shox/SHOX) Is Required for the Regulation of Cell Proliferation and Bone Differentiation in Zebrafish Embryo and Human Mesenchymal Stem Cells

The short-stature homeobox-containing gene (SHOX) was originally discovered as one of genes responsible for idiopathic short-stature syndromes in humans. Previous studies in animal models have shown the evolutionarily conserved link between this gene and skeletal formation in early embryogenesis. He...

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Bibliographic Details
Main Authors: Tomoaki Yokokura, Hiroyasu Kamei, Takashi Shibano, Daisuke Yamanaka, Rie Sawada-Yamaguchi, Fumihiko Hakuno, Shin-Ichiro Takahashi, Toshiaki Shimizu
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-06-01
Series:Frontiers in Endocrinology
Subjects:
SHOX
zebrafish embryo
human mesenchymal stem cells
proliferation
osteogenic differentiation
Online Access:http://journal.frontiersin.org/article/10.3389/fendo.2017.00125/full

Internet

http://journal.frontiersin.org/article/10.3389/fendo.2017.00125/full

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