NO-donating aspirin and aspirin partially inhibit age-related atherosclerosis but not radiation-induced atherosclerosis in ApoE null mice.

NO-donating aspirin and aspirin partially inhibit age-related atherosclerosis but not radiation-induced atherosclerosis in ApoE null mice.

BACKGROUND: We previously showed that irradiation to the carotid arteries of ApoE(-/-) mice accelerated the development of macrophage-rich, inflammatory atherosclerotic lesions, prone to intra-plaque hemorrhage. In this study we investigated the potential of anti-inflammatory and anti-coagulant inte...

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Bibliographic Details
Main Authors: Saske Hoving, Sylvia Heeneman, Marion J J Gijbels, Johannes A M te Poele, Manlio Bolla, Jeffrey F C Pol, Michelle Y Simons, Nicola S Russell, Mat J Daemen, Fiona A Stewart
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2943480?pdf=render

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http://europepmc.org/articles/PMC2943480?pdf=render

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