Condensations of single DNA molecules induced by heptaplatin and its chiral isomer
Heptaplatin is a third-generation platinum antitumor drug. It has a chiral isomer. We studied the interactions between the two isomers and DNA by using magnetic tweezers and atomic force microscopy (AFM) to investigate the effect of chiralities of the isomers on the interactions. We found that the e...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
AIP Publishing LLC
2014-08-01
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| Series: | AIP Advances |
| Online Access: | http://dx.doi.org/10.1063/1.4893672 |