Review of Tolvaptan’s Pharmacokinetic and Pharmacodynamic Properties and Drug Interactions

Review of Tolvaptan’s Pharmacokinetic and Pharmacodynamic Properties and Drug Interactions

Tolvaptan is an arginine vasopressin (AVP) antagonist that acts to increase excretion of free water (aquaresis) in patients without introducing electrolyte abnormalities or worsening renal function. It works via blockade of vasopressin-2 receptors at the renal collecting duct. Since the approval of...

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Bibliographic Details
Main Authors: Purav R. Bhatt, Elizabeth B. McNeely, Tess E. Lin, Kirkwood F. Adams, J. Herbert Patterson
Format: Article
Language:English
Published: MDPI AG 2014-11-01
Series:Journal of Clinical Medicine
Subjects:
tolvaptan
pharmacokinetic
pharmacodynamic
arginine vasopressin
aquaretic
CYP3A4
digoxin
heart failure
hyponatremia
Online Access:http://www.mdpi.com/2077-0383/3/4/1276

Internet

http://www.mdpi.com/2077-0383/3/4/1276

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