Human and rodent temporal lobe epilepsy is characterized by changes in O-GlcNAc homeostasis that can be reversed to dampen epileptiform activity

Human and rodent temporal lobe epilepsy is characterized by changes in O-GlcNAc homeostasis that can be reversed to dampen epileptiform activity

Temporal Lobe Epilepsy (TLE) is frequently associated with changes in protein composition and post-translational modifications (PTM) that exacerbate the disorder. O-linked-β-N-acetyl glucosamine (O-GlcNAc) is a PTM occurring at serine/threonine residues that is derived from and closely associated wi...

Full description

Bibliographic Details
Main Authors: Richard G. Sánchez, R. Ryley Parrish, Megan Rich, William M. Webb, Roxanne M. Lockhart, Kazuhito Nakao, Lara Ianov, Susan C. Buckingham, Devin R. Broadwater, Alistair Jenkins, Nihal C. de Lanerolle, Mark Cunningham, Tore Eid, Kristen Riley, Farah D. Lubin
Format: Article
Language:English
Published: Elsevier 2019-04-01
Series:Neurobiology of Disease
Subjects:
Hippocampus
Magnetic resonance imaging
Thiamet-G
Electroencephalogram
Electrophysiology
Mass spectrometry
Online Access:http://www.sciencedirect.com/science/article/pii/S096999611830370X

Internet

http://www.sciencedirect.com/science/article/pii/S096999611830370X

Similar Items