Protease-Activation of Fc-Masked Therapeutic Antibodies to Alleviate Off-Tumor Cytotoxicity

Protease-Activation of Fc-Masked Therapeutic Antibodies to Alleviate Off-Tumor Cytotoxicity

The interaction of the Fc region of therapeutic antibodies and antibody-drug conjugates with Fcγ receptors (FcγRs) can lead to unpredictable and severe side effects. Over the last decades several strategies have been developed to overcome this drawback, including extensive Fc- and glycoengineering a...

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Bibliographic Details
Main Authors: Adrian Elter, Desislava Yanakieva, David Fiebig, Kerstin Hallstein, Stefan Becker, Ulrich Betz, Harald Kolmar
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Immunology
Subjects:
Fc gamma receptor
off-target cytotoxicity
effector function
Fc-silencing
masked therapeutic antibody
MMP-9
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.715719/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.715719/full

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