Evidence for a Cyanine Link Between Propargylamine Drugs and Monoamine Oxidase Clarifies the Inactivation Mechanism

Evidence for a Cyanine Link Between Propargylamine Drugs and Monoamine Oxidase Clarifies the Inactivation Mechanism

Successful propargylamine drugs such as deprenyl inactivate monoamine oxidase (MAO), a target in multi-faceted approaches to prevent neurodegeneration in the aging population, but the chemical structure and mechanism of the irreversible inhibition are still debated. We characterized the covalent cya...

Full description

Bibliographic Details
Main Authors: Alen Albreht, Irena Vovk, Janez Mavri, Jose Marco-Contelles, Rona R. Ramsay
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Chemistry
Subjects:
monoamine oxidase
propargylamine
inhibition mechanism
structure
electrostatic interactions
quantum chemical calculations
Online Access:https://www.frontiersin.org/article/10.3389/fchem.2018.00169/full

Internet

https://www.frontiersin.org/article/10.3389/fchem.2018.00169/full

Similar Items