Attenuation of Hyperoxic Lung Injury in Newborn Thioredoxin-1-Overexpressing Mice through the Suppression of Proinflammatory Cytokine mRNA Expression

Attenuation of Hyperoxic Lung Injury in Newborn Thioredoxin-1-Overexpressing Mice through the Suppression of Proinflammatory Cytokine mRNA Expression

The role of thioredoxin-1 (TRX), a small redox-active protein with antioxidant effects, during hyperoxic lung injury in newborns remains undetermined. We investigated TRX impact on hyperoxic lung injury in newborn TRX transgenic (TRX-Tg) and wildtype (WT) mice exposed to 21% or 95% O<sub>2<...

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Bibliographic Details
Main Authors: Nobuhiko Nagano, Kosuke Tanaka, Junichi Ozawa, Takaaki Watanabe, Fuyu Miyake, Shun Matsumura, Kohei Osada, Kikumi Matsuoka, Masanori Tamura, Fumihiko Namba
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Biomedicines
Subjects:
antioxidant effects
hyperoxic lung injury
newborn mice
proinflammatory cytokine gene expression
thioredoxin-1
Online Access:https://www.mdpi.com/2227-9059/8/3/66

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https://www.mdpi.com/2227-9059/8/3/66

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