Streptolysin O concentration and activity is central to in vivo phenotype and disease outcome in Group A Streptococcus infection

Abstract Group A Streptoccocus (GAS) is among the most diverse of all human pathogens, responsible for a range of clinical manifestations, from mild superficial infections such as pharyngitis to serious invasive infections such as necrotising fasciitis and sepsis. The drivers of these different dise...

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Bibliographic Details
Main Authors: Jenny Clarke, Murielle Baltazar, Mansoor Alsahag, Stavros Panagiotou, Marion Pouget, William A. Paxton, Georgios Pollakis, Dean Everett, Neil French, Aras Kadioglu
Format: Article
Language:English
Published: Nature Publishing Group 2021-09-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-97866-4