Permeability of Novel Chitosan-g-Poly(Methyl Methacrylate) Amphiphilic Nanoparticles in a Model of Small Intestine In Vitro

Permeability of Novel Chitosan-g-Poly(Methyl Methacrylate) Amphiphilic Nanoparticles in a Model of Small Intestine In Vitro

Engineering of drug nanocarriers combining fine-tuned mucoadhesive/mucopenetrating properties is currently being investigated to ensure more efficient mucosal drug delivery. Aiming to improve the transmucosal delivery of hydrophobic drugs, we designed a novel nanogel produced by the self-assembly of...

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Bibliographic Details
Main Authors: Imrit Noi, Inbar Schlachet, Murali Kumarasamy, Alejandro Sosnik
Format: Article
Language:English
Published: MDPI AG 2018-04-01
Series:Polymers
Subjects:
Chitosan-g-PMMA amphiphilic nanoparticles
thiolated polymers
mucoadhesion
mucosal drug delivery
Caco-2 and HT29-MTX cell lines
apparent permeability in vitro
Online Access:http://www.mdpi.com/2073-4360/10/5/478

Internet

http://www.mdpi.com/2073-4360/10/5/478

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