Rett Syndrome and CDKL5 Deficiency Disorder: From Bench to Clinic

Rett Syndrome and CDKL5 Deficiency Disorder: From Bench to Clinic

Rett syndrome (RTT) and CDKL5 deficiency disorder (CDD) are two rare X-linked developmental brain disorders with overlapping but distinct phenotypic features. This review examines the impact of loss of methyl-CpG-binding protein 2 (MeCP2) and cyclin-dependent kinase-like 5 (CDKL5) on clinical phenot...

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Bibliographic Details
Main Authors: Shilpa D. Kadam, Brennan J. Sullivan, Archita Goyal, Mary E. Blue, Constance Smith-Hicks
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:International Journal of Molecular Sciences
Subjects:
glutamate toxicity
interneurons
seizures
sleep
preclinical modeling
clinical trials
Online Access:https://www.mdpi.com/1422-0067/20/20/5098

Internet

https://www.mdpi.com/1422-0067/20/20/5098

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