Population substructure and control selection in genome-wide association studies.

Population substructure and control selection in genome-wide association studies.

Determination of the relevance of both demanding classical epidemiologic criteria for control selection and robust handling of population stratification (PS) represents a major challenge in the design and analysis of genome-wide association studies (GWAS). Empirical data from two GWAS in European Am...

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Bibliographic Details
Main Authors: Kai Yu, Zhaoming Wang, Qizhai Li, Sholom Wacholder, David J Hunter, Robert N Hoover, Stephen Chanock, Gilles Thomas
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-07-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2432498?pdf=render

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http://europepmc.org/articles/PMC2432498?pdf=render

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