Tumor Heterogeneity, Single-Cell Sequencing, and Drug Resistance

Tumor Heterogeneity, Single-Cell Sequencing, and Drug Resistance

Tumor heterogeneity has been compared with Darwinian evolution and survival of the fittest. The evolutionary ecosystem of tumors consisting of heterogeneous tumor cell populations represents a considerable challenge to tumor therapy, since all genetically and phenotypically different subpopulations...

Full description

Bibliographic Details
Main Authors: Felix Schmidt, Thomas Efferth
Format: Article
Language:English
Published: MDPI AG 2016-06-01
Series:Pharmaceuticals
Subjects:
intratumoral heterogeneity
tumor ecosystems
single-cell sequencing
micromanipulation
laser-capture microdissection
flow cytometry
next generation sequencing
RNA sequencing
whole genome amplification
multi-region sequencing
circulating tumor cells
xenograft tumor models
cancer treatment
individualized therapy
precision medicine
Online Access:http://www.mdpi.com/1424-8247/9/2/33

Internet

http://www.mdpi.com/1424-8247/9/2/33

Similar Items