Effects of osmolytes and macromolecular crowders on stable GAAA tetraloops and their preference for a CG closing base pair

Osmolytes and macromolecular crowders have the potential to influence the stability of secondary structure motifs and alter preferences for conserved nucleic acid sequences in vivo. To further understand the cellular function of RNA we observed the effects of a model osmolyte, polyethylene glycol (P...

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Bibliographic Details
Main Authors: Kaethe N. Leonard, Joshua M. Blose
Format: Article
Language:English
Published: PeerJ Inc. 2018-02-01
Series:PeerJ
Subjects:
Online Access:https://peerj.com/articles/4236.pdf