Olmesartan decreased levels of IL-1β and TNF-α, down-regulated MMP-2, MMP-9, COX-2, RANK/RANKL and up-regulated SOCs-1 in an intestinal mucositis model.

Olmesartan decreased levels of IL-1β and TNF-α, down-regulated MMP-2, MMP-9, COX-2, RANK/RANKL and up-regulated SOCs-1 in an intestinal mucositis model.

Methotrexate (MTX) is a pro-oxidant compound that depletes dihydrofolate pools and is widely used in the treatment of leukaemia and other malignancies. The efficacy of methotrexate is often limited by mucositis and intestinal injury, which are major causes of morbidity in children and adults. The ai...

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Bibliographic Details
Main Authors: Raimundo Fernandes de Araújo, Maria Patrícia Oliveira da Silva Reinaldo, Gerly Anne de Castro Brito, Pedro de França Cavalcanti, Marco Aurélio Freire, Caroline Addison Xavier de Medeiros, Aurigena Antunes de Araújo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4273993?pdf=render

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http://europepmc.org/articles/PMC4273993?pdf=render

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