Integrating CAR T-Cell Therapy and Transplantation: Comparisons of Safety and Long-Term Efficacy of Allogeneic Hematopoietic Stem Cell Transplantation After CAR T-Cell or Chemotherapy-Based Complete Remission in B-Cell Acute Lymphoblastic Leukemia

Integrating CAR T-Cell Therapy and Transplantation: Comparisons of Safety and Long-Term Efficacy of Allogeneic Hematopoietic Stem Cell Transplantation After CAR T-Cell or Chemotherapy-Based Complete Remission in B-Cell Acute Lymphoblastic Leukemia

Patients often undergo consolidation allogeneic hematopoietic stem cell transplantation (allo-HSCT) to maintain long-term remission following chimeric antigen receptor (CAR) T-cell therapy. Comparisons of safety and efficacy of allo-HSCT following complete remission (CR) achieved by CAR-T therapy ve...

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Bibliographic Details
Main Authors: Yan-Li Zhao, De-Yan Liu, Rui-Juan Sun, Jian-Ping Zhang, Jia-Rui Zhou, Zhi-Jie Wei, Min Xiong, Xing-Yu Cao, Yue Lu, Jun-fang Yang, Xian Zhang, Dao-Pei Lu, Peihua Lu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Immunology
Subjects:
CD19 CAR T-cell therapy
relapse/refractory B cell acute lymphoblastic leukemia
allogeneic hematopoietic cell transplantation
survival
relapse
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.605766/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.605766/full

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