Exosomal LINC00174 derived from vascular endothelial cells attenuates myocardial I/R injury via p53-mediated autophagy and apoptosis

Exosomal LINC00174 derived from vascular endothelial cells attenuates myocardial I/R injury via p53-mediated autophagy and apoptosis

In this study, we aim to investigate the regulation of specific long non-coding RNAs (lncRNAs) on the progression of ischemia/reperfusion (I/R) injury. We identified and characterized the exosomes derived from mouse primary aortic endothelial cells. Subsequently, we found that these exosomes express...

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Bibliographic Details
Main Authors: Qiang Su, Xiang-Wei Lv, Yu-Li Xu, Ru-Ping Cai, Ri-Xin Dai, Xi-Heng Yang, Wei-Kun Zhao, Bing-Hui Kong
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
LINC00174
vascular endothelial cells
ischemia/reperfusion injury
p53
autophagy
apoptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253121000408

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http://www.sciencedirect.com/science/article/pii/S2162253121000408

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