Solubility Improvement of Benexate through Salt Formation Using Artificial Sweetener

Solubility Improvement of Benexate through Salt Formation Using Artificial Sweetener

Benexate, a drug used clinically as a defensive type anti-ulcer agent, has poor solubility and a bitter taste. To improve its solubility, a crystal engineering approach was proposed with the formation of novel salts using an artificial sweetener as a salt co-former. This was also expected to address...

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Bibliographic Details
Main Authors: Okky Dwichandra Putra, Daiki Umeda, Eriko Fujita, Tamami Haraguchi, Takahiro Uchida, Etsuo Yonemochi, Hidehiro Uekusa
Format: Article
Language:English
Published: MDPI AG 2018-05-01
Series:Pharmaceutics
Subjects:
benexate
crystal engineering
solubility
dissolution
sweetener
Online Access:http://www.mdpi.com/1999-4923/10/2/64

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