The ESX-5 System of Pathogenic Mycobacteria Is Involved In Capsule Integrity and Virulence through Its Substrate PPE10.

The ESX-5 System of Pathogenic Mycobacteria Is Involved In Capsule Integrity and Virulence through Its Substrate PPE10.

Mycobacteria produce a capsule layer, which consists of glycan-like polysaccharides and a number of specific proteins. In this study, we show that, in slow-growing mycobacteria, the type VII secretion system ESX-5 plays a major role in the integrity and stability of the capsule. We have identified P...

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Bibliographic Details
Main Authors: Louis S Ates, Aniek D van der Woude, Jovanka Bestebroer, Gunny van Stempvoort, René J P Musters, Juan J Garcia-Vallejo, Daisy I Picavet, Robert van de Weerd, Massimiliano Maletta, Coenraad P Kuijl, Nicole N van der Wel, Wilbert Bitter
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-06-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1005696

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https://doi.org/10.1371/journal.ppat.1005696

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