Phosphodiesterase 9A Inhibition Facilitates Corticostriatal Transmission in Wild-Type and Transgenic Rats That Model Huntington’s Disease

Phosphodiesterase 9A Inhibition Facilitates Corticostriatal Transmission in Wild-Type and Transgenic Rats That Model Huntington’s Disease

Huntington’s disease (HD) results from abnormal expansion in CAG trinucleotide repeats within the HD gene, a mutation which leads to degeneration of striatal medium-sized spiny neurons (MSNs), deficits in corticostriatal transmission, and loss of motor control. Recent studies also indicate that meta...

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Bibliographic Details
Main Authors: Shreaya Chakroborty, Fredric P. Manfredsson, Alexander M. Dec, Peter W. Campbell, Grace E. Stutzmann, Vahri Beaumont, Anthony R. West
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Neuroscience
Subjects:
phosphodiesterase 9A
Huntington’s disease
corticostriatal transmission
medium spiny neurons
fast-spiking interneurons
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2020.00466/full

Internet

https://www.frontiersin.org/article/10.3389/fnins.2020.00466/full

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