Thioguanine Induces Apoptosis in Triple-Negative Breast Cancer by Regulating PI3K–AKT Pathway

Thioguanine Induces Apoptosis in Triple-Negative Breast Cancer by Regulating PI3K–AKT Pathway

Triple-negative breast cancer (TNBC) is notoriously difficult to treat due to the lack of biological targets and poor sensitivity to conventional therapies. Chemotherapy is the main clinical therapy, but the effective screening strategy for chemotherapy drugs is poorly investigated. Drug repositioni...

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Bibliographic Details
Main Authors: Daoyu Zhang, Xinglan An, Qi Li, Xiaxia Man, Meiran Chu, Hao Li, Nan Zhang, Xiangpeng Dai, Hao Yu, Ziyi Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Oncology
Subjects:
triple-negative breast cancer
transcriptome
thioguanine
methylation
PI3K–AKT
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2020.524922/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2020.524922/full

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