Total Extracts of Abelmoschus manihot L. Attenuates Adriamycin-Induced Renal Tubule Injury via Suppression of ROS-ERK1/2-Mediated NLRP3 Inflammasome Activation

Total Extracts of Abelmoschus manihot L. Attenuates Adriamycin-Induced Renal Tubule Injury via Suppression of ROS-ERK1/2-Mediated NLRP3 Inflammasome Activation

Abelmoschus manihot (L.) Medik. (Malvaceae) is a herb used in traditional Chinese medicine to treat some kidney diseases. To date, the detailed mechanisms by which A. manihot improves some kinds of renal disease are not fully understood. In this study, we established Adriamycin-induced NRK-52E cells...

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Bibliographic Details
Main Authors: Wei Li, Weiming He, Ping Xia, Wei Sun, Ming Shi, Yao Zhou, Weiwei Zhu, Lu Zhang, Buhui Liu, Jingjing Zhu, Yiye Zhu, Enchao Zhou, Minjie Sun, Kun Gao
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Pharmacology
Subjects:
Abelmoschus manihot L.
total extract
renal tubular cell
Adriamycin nephropathy
oxidative stress
ERK1/2
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00567/full

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https://www.frontiersin.org/article/10.3389/fphar.2019.00567/full

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