Assessing the efficacy of protein farnesyltransferase inhibitors in mouse models of progeria

Assessing the efficacy of protein farnesyltransferase inhibitors in mouse models of progeria

Hutchinson-Gilford progeria syndrome (HGPS) is caused by the accumulation of a farnesylated form of prelamin A (progerin). Previously, we showed that blocking protein farnesylation with a farnesyltransferase inhibitor (FTI) ameliorates the disease phenotypes in mouse model of HGPS (LmnaHG/+). Howeve...

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Bibliographic Details
Main Authors: Shao H. Yang, Sandy Y. Chang, Douglas A. Andres, H. Peter Spielmann, Stephen G. Young, Loren G. Fong
Format: Article
Language:English
Published: Elsevier 2010-02-01
Series:Journal of Lipid Research
Subjects:
protein prenylation
farnesylation
posttranslational modifications
lamin A
aging
protein farnesyltransferase
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520305459

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http://www.sciencedirect.com/science/article/pii/S0022227520305459

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