Context-Dependent IL-1 mRNA-Destabilization by TTP Prevents Dysregulation of Immune Homeostasis Under Steady State Conditions

Context-Dependent IL-1 mRNA-Destabilization by TTP Prevents Dysregulation of Immune Homeostasis Under Steady State Conditions

The bioavailability of the major pro-inflammatory cytokines IL-1α and IL-1β is tightly controlled by transcription and post-translational processing to prevent hyperinflammation. The role of mRNA decay in maintenance of physiological IL-1 amounts remained unknown. Here we show that the down-regulati...

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Bibliographic Details
Main Authors: Lucy Sneezum, Kevin Eislmayr, Helene Dworak, Vitaly Sedlyarov, Anita Le Heron, Florian Ebner, Irmgard Fischer, Yoichiro Iwakura, Pavel Kovarik
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Immunology
Subjects:
mRNA stability
tristetraprolin
TTP
Zfp36
Interleukin 1beta
Interleukin 1alpha
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01398/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.01398/full

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