New 2,3-Benzodiazepine Derivative: Synthesis, Activity on Central Nervous System, and Toxicity Study in Mice

New 2,3-Benzodiazepine Derivative: Synthesis, Activity on Central Nervous System, and Toxicity Study in Mice

We report the design and synthesis of a new diazepine derivative, 4-(4-methoxyphenyl)-2,3,4,5-tetrahydro-2,3-benzodiazepin-1-one (VBZ102), and the evaluation of its anxiolytic-like profile, memory impairment effect, and toxicity in Swiss mice. VBZ102 was evaluated for central nervous system effects...

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Bibliographic Details
Main Authors: Amal Amaghnouje, Serhii Bohza, Nathalie Bohdan, Imane Es-Safi, Andrii Kyrylchuk, Sanae Achour, Hinde El Fatemi, Dalila Bousta, Andriy Grafov
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Pharmaceuticals
Subjects:
benzodiazepines
central nervous system
mouse behavioral model
toxicity
Online Access:https://www.mdpi.com/1424-8247/14/8/814

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https://www.mdpi.com/1424-8247/14/8/814

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