Extracellular matrix stiffness cues junctional remodeling for 3D tissue elongation

The extracellular matrix can shape developing organs, but how external forces direct intercellular morphogenesis is unclear. Here, the authors use 3D imaging to show that elongation of the Drosophila egg chamber involves polarized cell reorientation signalled by changes in stiffness of the surroundi...

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Main Authors:	Dong-Yuan Chen, Justin Crest, Sebastian J. Streichan, David Bilder
Format:	Article
Language:	English
Published:	Nature Publishing Group 2019-07-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-019-10874-x

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spelling	doaj-e771acac7c584a05a3c17ffd57e94efa2021-05-11T12:32:04ZengNature Publishing GroupNature Communications2041-17232019-07-0110111510.1038/s41467-019-10874-xExtracellular matrix stiffness cues junctional remodeling for 3D tissue elongationDong-Yuan Chen0Justin Crest1Sebastian J. Streichan2David Bilder3Department of Molecular and Cell Biology, University of California, BerkeleyDepartment of Molecular and Cell Biology, University of California, BerkeleyDepartment of Physics, University of California, Santa Barbara SantaDepartment of Molecular and Cell Biology, University of California, BerkeleyThe extracellular matrix can shape developing organs, but how external forces direct intercellular morphogenesis is unclear. Here, the authors use 3D imaging to show that elongation of the Drosophila egg chamber involves polarized cell reorientation signalled by changes in stiffness of the surrounding extracellular matrix.https://doi.org/10.1038/s41467-019-10874-x
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Dong-Yuan Chen Justin Crest Sebastian J. Streichan David Bilder
spellingShingle	Dong-Yuan Chen Justin Crest Sebastian J. Streichan David Bilder Extracellular matrix stiffness cues junctional remodeling for 3D tissue elongation Nature Communications
author_facet	Dong-Yuan Chen Justin Crest Sebastian J. Streichan David Bilder
author_sort	Dong-Yuan Chen
title	Extracellular matrix stiffness cues junctional remodeling for 3D tissue elongation
title_short	Extracellular matrix stiffness cues junctional remodeling for 3D tissue elongation
title_full	Extracellular matrix stiffness cues junctional remodeling for 3D tissue elongation
title_fullStr	Extracellular matrix stiffness cues junctional remodeling for 3D tissue elongation
title_full_unstemmed	Extracellular matrix stiffness cues junctional remodeling for 3D tissue elongation
title_sort	extracellular matrix stiffness cues junctional remodeling for 3d tissue elongation
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2019-07-01
description	The extracellular matrix can shape developing organs, but how external forces direct intercellular morphogenesis is unclear. Here, the authors use 3D imaging to show that elongation of the Drosophila egg chamber involves polarized cell reorientation signalled by changes in stiffness of the surrounding extracellular matrix.
url	https://doi.org/10.1038/s41467-019-10874-x
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Extracellular matrix stiffness cues junctional remodeling for 3D tissue elongation

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