Crystal structure of thrombin in complex with S-variegin: insights of a novel mechanism of inhibition and design of tunable thrombin inhibitors.

Crystal structure of thrombin in complex with S-variegin: insights of a novel mechanism of inhibition and design of tunable thrombin inhibitors.

The inhibition of thrombin is one of the important treatments of pathological blood clot formation. Variegin, isolated from the tropical bont tick, is a novel molecule exhibiting a unique 'two-modes' inhibitory property on thrombin active site (competitive before cleavage, noncompetitive a...

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Bibliographic Details
Main Authors: Cho Yeow Koh, Sundramurthy Kumar, Maria Kazimirova, Patricia A Nuttall, Uvaraj P Radhakrishnan, Seongcheol Kim, Pudur Jagadeeswaran, Takayuki Imamura, Jun Mizuguchi, Sadaaki Iwanaga, Kunchithapadam Swaminathan, R Manjunatha Kini
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3203879?pdf=render

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http://europepmc.org/articles/PMC3203879?pdf=render

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