An Efficient Protocol for the Synthesis of Carboacyclic Nucleosides via Aza-Conjugate Addition Reaction

A new efficient method for the synthesis of carboacyclic nucleosides as biologically interesting compounds via aza-conjugate addition of pyrimidine nucleobases to a,β-unsaturated esters in the presence of catalytic amount of LiOH.H2O (1.2-4.8 mol%) under microwave irradiation is described. This meth...

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Main Authors:	Mohammad Ali Zolfigol, Ardeshir Khazaei, Ahmad Reza Moosavi-Zare, Abdolkarim Zare, Ali Reza Hasanijejad
Format:	Article
Language:	English
Published:	Iranian Institute of Research and Development in Chemical Industries (IRDCI)-ACECR 2010-12-01
Series:	Iranian Journal of Chemistry & Chemical Engineering
Subjects:	carboacyclic nucleoside aza-conjugate addition reaction pyrimidine nucleobase  -unsaturated ester microwave
Online Access:	http://www.ijcce.ac.ir/article_6406_af1dd59e7f68c78ceed0b21ff2e77e8b.pdf

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spelling	doaj-e738b1f479ef4c08803f9319ea6c581c2020-11-25T02:54:03ZengIranian Institute of Research and Development in Chemical Industries (IRDCI)-ACECRIranian Journal of Chemistry & Chemical Engineering 1021-99861021-99862010-12-0129467736406An Efficient Protocol for the Synthesis of Carboacyclic Nucleosides via Aza-Conjugate Addition ReactionMohammad Ali Zolfigol0Ardeshir Khazaei1Ahmad Reza Moosavi-Zare2Abdolkarim Zare3Ali Reza Hasanijejad4Faculty of Chemistry, Bu-Ali Sina University, Hamedan, I.R. IRANFaculty of Chemistry, Bu-Ali Sina University, Hamedan, I.R. IRANFaculty of Chemistry, Bu-Ali Sina University, Hamedan, I.R. IRANDepartment of Chemistry, Payame Noor University (PNU), Tehran, I.R. IRANDepartment of Chemistry, Faculty of Sciences, Persian Gulf University, Bushehr, I.R. IRANA new efficient method for the synthesis of carboacyclic nucleosides as biologically interesting compounds via aza-conjugate addition of pyrimidine nucleobases to a,β-unsaturated esters in the presence of catalytic amount of LiOH.H2O (1.2-4.8 mol%) under microwave irradiation is described. This method affords the title compounds in good to excellent yields and in short reaction times.http://www.ijcce.ac.ir/article_6406_af1dd59e7f68c78ceed0b21ff2e77e8b.pdfcarboacyclic nucleosideaza-conjugate addition reactionpyrimidine nucleobase-unsaturated estermicrowave
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Mohammad Ali Zolfigol Ardeshir Khazaei Ahmad Reza Moosavi-Zare Abdolkarim Zare Ali Reza Hasanijejad
spellingShingle	Mohammad Ali Zolfigol Ardeshir Khazaei Ahmad Reza Moosavi-Zare Abdolkarim Zare Ali Reza Hasanijejad An Efficient Protocol for the Synthesis of Carboacyclic Nucleosides via Aza-Conjugate Addition Reaction Iranian Journal of Chemistry & Chemical Engineering carboacyclic nucleoside aza-conjugate addition reaction pyrimidine nucleobase  -unsaturated ester microwave
author_facet	Mohammad Ali Zolfigol Ardeshir Khazaei Ahmad Reza Moosavi-Zare Abdolkarim Zare Ali Reza Hasanijejad
author_sort	Mohammad Ali Zolfigol
title	An Efficient Protocol for the Synthesis of Carboacyclic Nucleosides via Aza-Conjugate Addition Reaction
title_short	An Efficient Protocol for the Synthesis of Carboacyclic Nucleosides via Aza-Conjugate Addition Reaction
title_full	An Efficient Protocol for the Synthesis of Carboacyclic Nucleosides via Aza-Conjugate Addition Reaction
title_fullStr	An Efficient Protocol for the Synthesis of Carboacyclic Nucleosides via Aza-Conjugate Addition Reaction
title_full_unstemmed	An Efficient Protocol for the Synthesis of Carboacyclic Nucleosides via Aza-Conjugate Addition Reaction
title_sort	efficient protocol for the synthesis of carboacyclic nucleosides via aza-conjugate addition reaction
publisher	Iranian Institute of Research and Development in Chemical Industries (IRDCI)-ACECR
series	Iranian Journal of Chemistry & Chemical Engineering
issn	1021-9986 1021-9986
publishDate	2010-12-01
description	A new efficient method for the synthesis of carboacyclic nucleosides as biologically interesting compounds via aza-conjugate addition of pyrimidine nucleobases to a,β-unsaturated esters in the presence of catalytic amount of LiOH.H2O (1.2-4.8 mol%) under microwave irradiation is described. This method affords the title compounds in good to excellent yields and in short reaction times.
topic	carboacyclic nucleoside aza-conjugate addition reaction pyrimidine nucleobase  -unsaturated ester microwave
url	http://www.ijcce.ac.ir/article_6406_af1dd59e7f68c78ceed0b21ff2e77e8b.pdf
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An Efficient Protocol for the Synthesis of Carboacyclic Nucleosides via Aza-Conjugate Addition Reaction

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