Whole-exome sequencing identifies novel mutations in ABC transporter genes associated with intrahepatic cholestasis of pregnancy disease: a case-control study

Whole-exome sequencing identifies novel mutations in ABC transporter genes associated with intrahepatic cholestasis of pregnancy disease: a case-control study

Abstract Background Intrahepatic cholestasis of pregnancy (ICP) can cause premature delivery and stillbirth. Previous studies have reported that mutations in ABC transporter genes strongly influence the transport of bile salts. However, to date, their effects are still largely elusive. Methods A who...

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Bibliographic Details
Main Authors: Xianxian Liu, Hua Lai, Siming Xin, Zengming Li, Xiaoming Zeng, Liju Nie, Zhengyi Liang, Meiling Wu, Jiusheng Zheng, Yang Zou
Format: Article
Language:English
Published: BMC 2021-02-01
Series:BMC Pregnancy and Childbirth
Subjects:
ICP
WES
TBA
ABC transporter genes
Genetic variants
ABCC2 gene
Online Access:https://doi.org/10.1186/s12884-021-03595-x

Internet

https://doi.org/10.1186/s12884-021-03595-x

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