Quantitation of two pathways for cholesterol excretion from the brain in normal mice and mice with neurodegeneration

Quantitation of two pathways for cholesterol excretion from the brain in normal mice and mice with neurodegeneration

Although the pool of cholesterol in the adult central nervous system (CNS) is large and of constant size, little is known of the process(es) involved in regulation of sterol turnover in this pool. In 7-week-old mice, net excretion of cholesterol from the brain equaled 1.4 mg/day/kg body weight, and...

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Bibliographic Details
Main Authors: Chonglun Xie, Erik G. Lund, Stephen D. Turley, David W. Russell, John M. Dietschy
Format: Article
Language:English
Published: Elsevier 2003-09-01
Series:Journal of Lipid Research
Subjects:
Niemann-Pick type C disease
dementia
glial cells
oxysterols
cholesterol 24-hydroxylase
sterol 27-hydroxylase
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520337433

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http://www.sciencedirect.com/science/article/pii/S0022227520337433

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